"I wanted to do my first boy/girl with Nica because she understands talent better than anyone, and I know she'll make it comfortable for me," Ryan said.
Ryan performed "a handful" of boy/girl scenes several years ago before switching to girl/girl only.
"I didn't feel attracted to most of the guys, and I didn't enjoy it," Ryan said. "I thought about trying it again, but I wanted to work with directors who set the bar a little higher."
In the feature, Ferrara plays a gigolo who falls unexpectedly in love with Ryan.
"Manuel is very real, and I think that will help me as far as feeling comfortable," says Ryan. "In other words, he won't just be 'fucking' me."
"Gigolos" will shoot later this month for release in early 2010.
Sweet Sinner Films is operated by the owners of lesbian-content production company Sweetheart Video.
"We're very happy to have Samantha at Sweet Sinner," said Jon B, Sweetheart Video and Sweet Sinner Films owner. "She's one of our top girl/girl performers, and we expect her boy/girl scenes to be just as amazing."